| Host: |
Mouse |
| Applications: |
FA/FC |
| Reactivity: |
Human |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Integrin alpha-L is suitable for use in FA and Flow Cytometry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
R7-1 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1k |
| Formulation: |
0.2 µm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as determined by LAL gel clotting assay. |
| Concentration: |
0.5 mg/mL |
| Storage Instruction: |
Store at 2-8°C. Do not freeze this product. |
| Tissue Specificity | Leukocytes. |
| Post Translational Modifications | In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents. |
| Function | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. |
| Protein Name | Integrin Alpha-LCd11 Antigen-Like Family Member ALeukocyte Adhesion Glycoprotein Lfa-1 Alpha ChainLfa-1aLeukocyte Function-Associated Molecule 1 Alpha ChainCd Antigen Cd11a |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-6798695Reactome: R-HSA-8949275 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-L antibodyAnti-Cd11 Antigen-Like Family Member A antibodyAnti-Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain antibodyAnti-Lfa-1a antibodyAnti-Leukocyte Function-Associated Molecule 1 Alpha Chain antibodyAnti-Cd Antigen Cd11a antibodyAnti-ITGAL antibodyAnti-CD11A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
