• C57BL/6 murine splenocytes were stained with Anti-CD11a antibody (STJA0000315) [Used at 0.02 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained splenocytes (empty black histogram) were used as control.

Anti-CD11a/Itgal antibody [FD441.8] {PE} (STJA0000315)

SKU:
STJA0000315

Current Stock:
Host: Rat
Applications: FC
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-Integrin alpha-L is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: FD441.8
Conjugation: PE
Isotype: IgG2bk
Formulation: PBS with 0.05% Proclin300, 1% BSA
Concentration: 0.2 mg/mL
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: Itgal
Gene ID: 16408
Uniprot ID: ITAL_MOUSE
Tissue Specificity Leukocytes.
Post Translational Modifications In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for the activation by some physiological agents.
Function Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Protein Name Integrin Alpha-L
Cd11 Antigen-Like Family Member A
Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain
Lfa-1a
Leukocyte Function-Associated Molecule 1 Alpha Chain
Lymphocyte Antigen 15
Ly-15
Cd Antigen Cd11a
Database Links Reactome: R-MMU-198933
Reactome: -MMU-202733
Reactome: -MMU-216083
Reactome: -MMU-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Integrin Alpha-L antibody
Anti-Cd11 Antigen-Like Family Member A antibody
Anti-Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain antibody
Anti-Lfa-1a antibody
Anti-Leukocyte Function-Associated Molecule 1 Alpha Chain antibody
Anti-Lymphocyte Antigen 15 antibody
Anti-Ly-15 antibody
Anti-Cd Antigen Cd11a antibody
Anti-Itgal antibody
Anti-Lfa-1 antibody
Anti-Ly-15 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance