Anti-CD119 antibody (26-250 aa) (STJ11105176)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CD119 (26-250 aa) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Ifngr1 |
| Gene ID | 15979 |
| Uniprot ID | INGR1_MOUSE |
| Immunogen Region | 26-250 aa |
| Immunogen Sequence | ALTSTEDPEPPSVPVPTNVL IKSYNLNPVVCWEYQNMSQT PIFTVQVKVYSGSWTDSCTN ISDHCCNIYEQIMYPDVSAW ARVKAKVGQKESDYARSKEF LMCLKGKVGPPGLEIRRKKE EQLSVLVFHPEVVVNGESQG TMFGDGSTCYTFDYTVYVEH NRSGEILHTKHTVEKEECNE TLCELNISVSTLDSRYCISV DGISSFWQVRTEKSKDVCIP PFHDD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 26-250 of mouse CD119. (NP_034641.1). |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser/Thr residues. Phosphorylation of Tyr-445 is required for IFNG receptor signal transduction. Influenza virus infection leads to phosphorylation in a CSNK1A1-dependent manner. Ubiquitinated after phosphorylation in a CSNK1A1-dependent manner, leading to the lysosome-dependent degradation. Proteasomally degraded through 'Lys-48'-mediated ubiquitination. Ubiquitination is necessary for efficient IFNGR1 signaling. |
| Function | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (, PubMed:20926559, PubMed:27286456). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to its dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1. |
| Protein Name | Interferon Gamma Receptor 1Ifn-Gamma Receptor 1Ifn-Gamma-R1Interferon Gamma Receptor Alpha-ChainIfn-Gamma-R-AlphaCd Antigen Cd119 |
| Database Links | Reactome: R-MMU-877300Reactome: -MMU-877312Reactome: -MMU-9732724 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interferon Gamma Receptor 1 antibodyAnti-Ifn-Gamma Receptor 1 antibodyAnti-Ifn-Gamma-R1 antibodyAnti-Interferon Gamma Receptor Alpha-Chain antibodyAnti-Ifn-Gamma-R-Alpha antibodyAnti-Cd Antigen Cd119 antibodyAnti-Ifngr1 antibodyAnti-Ifngr antibody |
Information sourced from Uniprot.org