Anti-CD112 antibody (32-345 aa) (STJ11105181)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CD112 (32-345 aa) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Nectin2 |
| Gene ID | 19294 |
| Uniprot ID | NECT2_MOUSE |
| Immunogen Region | 32-345 aa |
| Immunogen Sequence | QDVRVRVLPEVRGRLGGTVE LPCHLLPPTTERVSQVTWQR LDGTVVAAFHPSFGVDFPNS QFSKDRLSFVRARPETNADL RDATLAFRGLRVEDEGNYTC EFATFPNGTRRGVTWLRVIA QPENHAEAQEVTIGPQSVAV ARCVSTGGRPPARITWISSL GGEAKDTQEPGIQAGTVTII SRYSLVPVGRADGVKVTCRV EHESFEEPILLPVTLSVRYP PEVSISGYDDNWYLGRSEA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 32-345 of mouse CD112. (NP_033016.3). |
Additional Info
| Tissue Specificity | Brain, spinal cord, spleen, kidney, heart and liver. |
| Function | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. |
| Protein Name | Nectin-2Herpes Virus Entry Mediator BHerpesvirus Entry Mediator BHvebMurine Herpes Virus Entry Protein BMhvebNectin Cell Adhesion Molecule 2Poliovirus Receptor HomologPoliovirus Receptor-Related Protein 2Cd Antigen Cd112 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-418990Reactome: -MMU-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Nectin-2 antibodyAnti-Herpes Virus Entry Mediator B antibodyAnti-Herpesvirus Entry Mediator B antibodyAnti-Hveb antibodyAnti-Murine Herpes Virus Entry Protein B antibodyAnti-Mhveb antibodyAnti-Nectin Cell Adhesion Molecule 2 antibodyAnti-Poliovirus Receptor Homolog antibodyAnti-Poliovirus Receptor-Related Protein 2 antibodyAnti-Cd Antigen Cd112 antibodyAnti-Nectin2 antibodyAnti-Mph antibodyAnti-Pvr antibodyAnti-Pvrl2 antibodyAnti-Pvs antibody |
Information sourced from Uniprot.org