Anti-CD110/MPL antibody [VB22B] {FITC} (STJA0028448)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationFITC
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal Thrombopoietin Receptor antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | VB22B |
| Isotype | IgG1k |
| Conjugation | FITC |
| Concentration | 05 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months Protect from light Do not freeze |
Target Information
| Gene Symbol | MPL |
| Gene ID | 4352 |
| Uniprot ID | TPOR_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylated at Tyr-591 in response to THPO stimulation. Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways. The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination. |
| Function | Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production. |
| Protein Name | Thrombopoietin ReceptorTpo-RMyeloproliferative Leukemia ProteinProto-Oncogene C-MplCd Antigen Cd110 |
| Database Links | Reactome: R-HSA-76009 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusCell Surface |
| Alternative Antibody Names | Anti-Thrombopoietin Receptor antibodyAnti-Tpo-R antibodyAnti-Myeloproliferative Leukemia Protein antibodyAnti-Proto-Oncogene C-Mpl antibodyAnti-Cd Antigen Cd110 antibodyAnti-MPL antibodyAnti-TPOR antibody |
Information sourced from Uniprot.org