| Host: |
Rat |
| Applications: |
FC/IF |
| Reactivity: |
Mouse |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rat monoclonal antibody anti-Vascular cell adhesion protein 1 is suitable for use in Flow Cytometry and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
M/K-2.7 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1k |
| Formulation: |
0.2 µm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as determined by LAL gel clotting assay. |
| Concentration: |
0.5 mg/mL |
| Storage Instruction: |
Store at 2-8°C. Do not freeze this product. |
| Tissue Specificity | Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow. |
| Post Translational Modifications | Cleaved by the metalloproteinase ADAM17 to generate the soluble form. Sialoglycoprotein. Ubiquitinated by TRIM65 via 'Lys-48'-linked ubiquitination.leading to proteasomal degradation. |
| Function | Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation. |
| Protein Name | Vascular Cell Adhesion Protein 1V-Cam 1Vcam-1Cd Antigen Cd106 Cleaved Into - Soluble Vascular Cell Adhesion Molecule-1 |
| Cellular Localisation | Vascular Cell Adhesion Protein 1: Cell MembraneSingle-Pass Type I Membrane ProteinSoluble Vascular Cell Adhesion Molecule-1: Secreted |
| Alternative Antibody Names | Anti-Vascular Cell Adhesion Protein 1 antibodyAnti-V-Cam 1 antibodyAnti-Vcam-1 antibodyAnti-Cd Antigen Cd106 Cleaved Into - Soluble Vascular Cell Adhesion Molecule-1 antibodyAnti-Vcam1 antibodyAnti-Vcam-1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![C57BL/6 murine bone marrow cells were stained with Anti-CD106 antibody (STJA0000481) [Used at 0.2 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained bone marrow cells (empty black histogram) were used as control.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/145334/291997/STJA0000481_1__88104.1631205826.jpg?c=1 "C57BL/6 murine bone marrow cells were stained with Anti-CD106 antibody (STJA0000481) [Used at 0.2 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained bone marrow cells (empty black histogram) were used as control.")
