Anti-CD105/Eng antibody [MJ7/18] {FITC} (STJA0002565)

SKU:
STJA0002565

$191.03 - $323.33
Current Stock:
Host: Rat
Applications: FC
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-Endoglin is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: MJ7/18
Conjugation: FITC
Isotype: IgG2ak
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: Eng
Gene ID: 13805
Uniprot ID: EGLN_MOUSE
Tissue Specificity Detected on blood vessels (at protein level). Detected on adult pulmonary artery, capillaries supporting the heart muscle and lung alveolar capillary endothelial cells. Endoglin is restricted to endothelial cells in all tissues except bone marrow and is also found in stromal cells within the connective tissue of intestine, stomach, heart, skeletal muscle, uterus, ovary, oviduct, testis and thymus.
Function Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. May play a role in the binding of endothelial cells to integrins. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3.
Protein Name Endoglin
Cell Surface Mj7/18 Antigen
Cd Antigen Cd105
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Endoglin antibody
Anti-Cell Surface Mj7/18 Antigen antibody
Anti-Cd Antigen Cd105 antibody
Anti-Eng antibody
Anti-Edg antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance