Anti-CD105 antibody [SN6] {EF488} (STJA0016542)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationEF488
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal anti-Endoglin for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SN6 |
| Isotype | IgG1k |
| Conjugation | EF488 |
| Concentration | 5 Mu L/Test |
| Purification | Affinity purified |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8Β°C and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | ENG |
| Gene ID | 2022 |
| Uniprot ID | EGLN_HUMAN |
Additional Info
| Tissue Specificity | Detected on umbilical veil endothelial cells. Detected in placenta (at protein level). Detected on endothelial cells. |
| Function | Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3. |
| Protein Name | EndoglinCd Antigen Cd105 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Endoglin antibodyAnti-Cd Antigen Cd105 antibodyAnti-ENG antibodyAnti-END antibody |
Information sourced from Uniprot.org