| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CD105 (27-581) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Eng |
| Gene ID: |
13805 |
| Uniprot ID: |
EGLN_MOUSE |
| Immunogen Region: |
27-581 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 27-581 of mouse CD105 (NP_031958.2). |
| Immunogen Sequence: |
ERVGCDLQPVDPTRGEVTFT TSQVSEGCVAQAANAVREVH VLFLDFPGMLSHLELTLQAS KQNGTETQEVFLVLVSNKNV FVKFQAPEIPLHLAYDSSLV IFQGQPRVNITVLPSLTSRK QILDWAATKGAITSIAALDD PQSIVLQLGQDPKAPFLCLP EAHKDMGATLEWQPRAQTPV QSCRLEGVSGHKEAYILRIL PGSEAGPRTVTVMMELSCTS GDAILILHGPPYVSWFIDI |
| Tissue Specificity | Detected on blood vessels (at protein level). Detected on adult pulmonary artery, capillaries supporting the heart muscle and lung alveolar capillary endothelial cells. Endoglin is restricted to endothelial cells in all tissues except bone marrow and is also found in stromal cells within the connective tissue of intestine, stomach, heart, skeletal muscle, uterus, ovary, oviduct, testis and thymus. |
| Function | Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. May play a role in the binding of endothelial cells to integrins. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3. |
| Protein Name | EndoglinCell Surface Mj7/18 AntigenCd Antigen Cd105 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Endoglin antibodyAnti-Cell Surface Mj7/18 Antigen antibodyAnti-Cd Antigen Cd105 antibodyAnti-Eng antibodyAnti-Edg antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
