Anti-CD104/ITGB4 antibody [65A12] (STJA0026932)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal Integrin Beta-4 antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 65A12 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1.48 mg/ml |
| Purification | Protein A/G purified from cell culture supernatant. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | ITGB4 |
| Gene ID | 3691 |
| Uniprot ID | ITB4_HUMAN |
Additional Info
| Post Translational Modifications | Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secondary association with tertaspanins. |
| Function | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. |
| Protein Name | Integrin Beta-4Gp150Cd Antigen Cd104 |
| Database Links | Reactome: R-HSA-2022090Reactome: R-HSA-3000157Reactome: R-HSA-3000170Reactome: R-HSA-446107Reactome: R-HSA-9725554 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLipid-AnchorCell JunctionHemidesmosomeColocalizes With Dst At The Leading Edge Of Migrating Keratinocytes |
| Alternative Antibody Names | Anti-Integrin Beta-4 antibodyAnti-Gp150 antibodyAnti-Cd Antigen Cd104 antibodyAnti-ITGB4 antibody |
Information sourced from Uniprot.org