||FOR RESEARCH USE ONLY (RUO).
||Mouse monoclonal antibody anti-CD101 is suitable for use in Flow Cytometry research applications.
||PBS with 0.09% sodium azide and 1% BSA
||Store at 2-8°C upon receipt.
| Tissue Specificity || Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients. |
| Post Translational Modifications || N-glycosylated. |
| Function || Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. |
| Protein Name || Immunoglobulin Superfamily Member 2Igsf2Cell Surface Glycoprotein V7Glu-Trp-Ile Ewi Motif-Containing Protein 101Ewi-101Cd Antigen Cd101 |
| Database Links || Reactome: R-HSA-202433 |
| Cellular Localisation || MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names || Anti-Immunoglobulin Superfamily Member 2 antibodyAnti-Igsf2 antibodyAnti-Cell Surface Glycoprotein V7 antibodyAnti-Glu-Trp-Ile Ewi Motif-Containing Protein 101 antibodyAnti-Ewi-101 antibodyAnti-Cd Antigen Cd101 antibodyAnti-CD101 antibodyAnti-EWI101 antibodyAnti-IGSF2 antibodyAnti-V7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance