Anti-CD101 antibody [BB27] {FITC} (STJ16100561)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationFITC
IsotypeIgG1
ImmunogenHuman thymic clone B12.
General Information
| Short Description | Mouse monoclonal anti-CD101 for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | BB27 |
| Isotype | IgG1 |
| Conjugation | FITC |
| Concentration | 0.1 mg/mL |
| Formulation | PBS with 0.09% sodium azide and 1% BSA |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | CD101 |
| Gene ID | 9398 |
| Uniprot ID | IGSF2_HUMAN |
| Immunogen | Human thymic clone B12. |
Additional Info
| Tissue Specificity | Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients. |
| Post Translational Modifications | N-glycosylated. |
| Function | Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. |
| Protein Name | Immunoglobulin Superfamily Member 2Igsf2Cell Surface Glycoprotein V7Glu-Trp-Ile Ewi Motif-Containing Protein 101Ewi-101Cd Antigen Cd101 |
| Database Links | Reactome: R-HSA-202433 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Immunoglobulin Superfamily Member 2 antibodyAnti-Igsf2 antibodyAnti-Cell Surface Glycoprotein V7 antibodyAnti-Glu-Trp-Ile Ewi Motif-Containing Protein 101 antibodyAnti-Ewi-101 antibodyAnti-Cd Antigen Cd101 antibodyAnti-CD101 antibodyAnti-EWI101 antibodyAnti-IGSF2 antibodyAnti-V7 antibody |
Information sourced from Uniprot.org