• Western blot analysis of lysates from wild type (WT) and 293T cells transfected with CD101, using CD101 Rabbit polyclonal antibody (STJ11105359) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.

Anti-CD101 antibody (21-410) (STJ11105359)

SKU:
STJ11105359

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Immunoglobulin Superfamily Member 2 (21-410) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CD101
Gene ID: 9398
Uniprot ID: IGSF2_HUMAN
Immunogen Region: 21-410
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 21-410 of human CD101 (NP_004249.2).
Immunogen Sequence: QREVTVQKGPLFRAEGYPVS IGCNVTGHQGPSEQHFQWSV YLPTNPTQEVQIISTKDAAF SYAVYTQRVRSGDVYVERVQ GNSVLLHISKLQMKDAGEYE CHTPNTDEKYYGSYSAKTNL IVIPDTLSATMSSQTLGKEE GEPLALTCEASKATAQHTHL SVTWYLTQDGGGSQATEIIS LSKDFILVPGPLYTERFAAS DVQLNKLGPTTFRLSIERLQ SSDQGQLFCEATEWIQDPD
Tissue Specificity Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients.
Post Translational Modifications N-glycosylated.
Function Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.
Protein Name Immunoglobulin Superfamily Member 2
Igsf2
Cell Surface Glycoprotein V7
Glu-Trp-Ile Ewi Motif-Containing Protein 101
Ewi-101
Cd Antigen Cd101
Database Links Reactome: R-HSA-202433
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Immunoglobulin Superfamily Member 2 antibody
Anti-Igsf2 antibody
Anti-Cell Surface Glycoprotein V7 antibody
Anti-Glu-Trp-Ile Ewi Motif-Containing Protein 101 antibody
Anti-Ewi-101 antibody
Anti-Cd Antigen Cd101 antibody
Anti-CD101 antibody
Anti-EWI101 antibody
Anti-IGSF2 antibody
Anti-V7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance