| Short Description : | Rabbit polyclonal CCT5 (1-270) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCT5 |
| Gene ID: | 22948 |
| Uniprot ID: | TCPE_HUMAN |
| Immunogen Region: | 1-270 |
| Immunogen Sequence: | MASMGTLAFDEYGRPFLIIK DQDRKSRLMGLEALKSHIMA AKAVANTMRTSLGPNGLDKM MVDKDGDVTVTNDGATILSM MDVDHQIAKLMVELSKSQDD EIGDGTTGVVVLAGALLEEA EQLLDRGIHPIRIADGYEQA ARVAIEHLDKISDSVLVDIK DTEPLIQTAKTTLGSKVVNS CHRQMAEIAVNAVLTVADME RRDVDFELIKVEGKVGGRLE DTKLIKGVIVDKDFSHPQM |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CCT5 (NP_036205.1). |
| Post Translational Modifications | Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation. |
| Function | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. |
| Protein Name | T-Complex Protein 1 Subunit EpsilonTcp-1-EpsilonCct-EpsilonChaperonin Containing T-Complex Polypeptide 1 Subunit 5 |
| Database Links | Reactome: R-HSA-389957Reactome: R-HSA-389960Reactome: R-HSA-390450Reactome: R-HSA-390471Reactome: R-HSA-5620922Reactome: R-HSA-6814122 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosome |
| Alternative Antibody Names | Anti-T-Complex Protein 1 Subunit Epsilon antibodyAnti-Tcp-1-Epsilon antibodyAnti-Cct-Epsilon antibodyAnti-Chaperonin Containing T-Complex Polypeptide 1 Subunit 5 antibodyAnti-CCT5 antibodyAnti-CCTE antibodyAnti-KIAA0098 antibody |
Information sourced from Uniprot.org
