Anti-CCS antibody (1-274) (STJ28886)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CCS (1-274) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CCS |
| Gene ID | 9973 |
| Uniprot ID | CCS_HUMAN |
| Immunogen Region | 1-274 |
| Immunogen Sequence | MASDSGNQGTLCTLEFAVQM TCQSCVDAVRKSLQGVAGVQ DVEVHLEDQMVLVHTTLPSQ EVQALLEGTGRQAVLKGMGS GQLQNLGAAVAILGGPGTVQ GVVRFLQLTPERCLIEGTID GLEPGLHGLHVHQYGDLTNN CNSCGNHFNPDGASHGGPQD SDRHRGDLGNVRADADGRAI FRMEDEQLKVWDVIGRSLII DEGEDDLGRGGHPLSKITGN SGERLACGIIARSAGLFQN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human CCS (NP_005116.1). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241. |
| Function | Delivers copper to copper zinc superoxide dismutase (SOD1). |
| Protein Name | Copper Chaperone For Superoxide DismutaseSuperoxide Dismutase Copper Chaperone |
| Database Links | Reactome: R-HSA-3299685 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Copper Chaperone For Superoxide Dismutase antibodyAnti-Superoxide Dismutase Copper Chaperone antibodyAnti-CCS antibody |
Information sourced from Uniprot.org