Anti-CCNK antibody (1-160) (STJ112299)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CCNK (1-160) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CCNK |
| Gene ID | 8812 |
| Uniprot ID | CCNK_HUMAN |
| Immunogen Region | 1-160 |
| Immunogen Sequence | MKENKENSSPSVTSANLDHT KPCWYWDKKDLAHTPSQLEG LDPATEARYRREGARFIFDV GTRLGLHYDTLATGIIYFHR FYMFHSFKQFPRYVTGACCL FLAGKVEETPKKCKDIIKTA RSLLNDVQFGQFGDDPKEEV MVLERILLQTIKFDLQVEHP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human Cyclin K (NP_001092872.1). |
Additional Info
| Tissue Specificity | Widely expressed. Highest levels in testis. |
| Function | Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). |
| Protein Name | Cyclin-K |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-167152Reactome: R-HSA-167287Reactome: R-HSA-167290Reactome: R-HSA-2173796Reactome: R-HSA-674695Reactome: R-HSA-6796648Reactome: R-HSA-6807505Reactome: R-HSA-75955 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclin-K antibodyAnti-CCNK antibodyAnti-CPR4 antibody |
Information sourced from Uniprot.org