• Western blot analysis of extracts of various cell lines, using Cyclin H antibody (STJ11104592) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Anti-CCNH antibody (1-100) [S4592RM] (STJ11104592)

SKU:
STJ11104592

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Cyclin-H (1-100) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S4592RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCNH
Gene ID: 902
Uniprot ID: CCNH_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Cyclin H (P51946).
Immunogen Sequence: MYHNSSQKRHWTFSSEEQLA RLRADANRKFRCKAVANGKV LPNDPVFLEPHEEMTLCKYY EKRLLEFCSVFKPAMPRSVV GTACMYFKRFYLNNSVMEYH
Function Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Protein Name Cyclin-H
Mo15-Associated Protein
P34
P37
Database Links Reactome: R-HSA-112382
Reactome: R-HSA-113418
Reactome: R-HSA-167152
Reactome: R-HSA-167158
Reactome: R-HSA-167160
Reactome: R-HSA-167161
Reactome: R-HSA-167162
Reactome: R-HSA-167172
Reactome: R-HSA-167200
Reactome: R-HSA-167246
Reactome: R-HSA-427413
Reactome: R-HSA-5696395
Reactome: R-HSA-674695
Reactome: R-HSA-6781823
Reactome: R-HSA-6781827
Reactome: R-HSA-6782135
Reactome: R-HSA-6782210
Reactome: R-HSA-6796648
Reactome: R-HSA-69202
Reactome: R-HSA-69231
Reactome: R-HSA-69273
Reactome: R-HSA-69656
Reactome: R-HSA-72086
Reactome: R-HSA-73762
Reactome: R-HSA-73772
Reactome: R-HSA-73776
Reactome: R-HSA-73779
Reactome: R-HSA-73863
Reactome: R-HSA-75953
Reactome: R-HSA-75955
Reactome: R-HSA-76042
Reactome: R-HSA-77075
Reactome: R-HSA-8939236
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Cyclin-H antibody
Anti-Mo15-Associated Protein antibody
Anti-P34 antibody
Anti-P37 antibody
Anti-CCNH antibody

Information sourced from Uniprot.org

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