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Anti-CCNE1 antibody (N-Term) (STJA0005672)

Anti-CCNE1 antibody (N-Term) (STJA0005672)

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STJA0005672-100

£455.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cyclin E1 (N-Term) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS + 0.02% NaN3
Purification:	Antigen Affinity Purified
Dilution Range:	WB 1:500-1:1000 IHC ICC IP
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CCNE1
Gene ID:	898
Uniprot ID:	CCNE1_HUMAN
Immunogen Region:	N-Term
Specificity:	Reacts with the N-terminal region of human Cyclin E1 protein
Immunogen:	Synthetic peptide corresponding to amino acids from the N-terminal region of human Cyclin E1 protein

Post Translational Modifications	Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7. Ubiquitinated by UHRF2.appears to occur independently of phosphorylation.
Function	Essential for the control of the cell cycle at the G1/S (start) transition.
Protein Name	G1/S-Specific Cyclin-E1
Database Links	Reactome: R-HSA-1538133 Reactome: R-HSA-187577 Reactome: R-HSA-2559586 Reactome: R-HSA-390471 Reactome: R-HSA-6804116 Reactome: R-HSA-69017 Reactome: R-HSA-69200 Reactome: R-HSA-69202 Reactome: R-HSA-69205 Reactome: R-HSA-69231 Reactome: R-HSA-69563 Reactome: R-HSA-8849470 Reactome: R-HSA-9661069 Reactome: R-HSA-9706019
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-G1/S-Specific Cyclin-E1 antibody Anti-CCNE1 antibody Anti-CCNE antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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