| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCNC |
| Gene ID: | 892 |
| Uniprot ID: | CCNC_HUMAN |
| Immunogen Region: | 1-283 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human Cyclin C (NP_005181.2). |
| Immunogen Sequence: | MAGNFWQSSHYLQWILDKQD LLKERQKDLKFLSEEEYWKL QIFFTNVIQALGEHLKLRQQ VIATATVYFKRFYARYSLKS IDPVLMAPTCVFLASKVEEF GVVSNTRLIAAATSVLKTRF SYAFPKEFPYRMNHILECEF YLLELMDCCLIVYHPYRPLL QYVQDMGQEDMLLPLAWRIV NDTYRTDLCLLYPPFMIALA CLHVACVVQQKDARQWFAEL SVDMEKILEIIRVILKLYE |
| Tissue Specificity | Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain. |
| Function | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. |
| Protein Name | Cyclin-CSrb11 HomologHsrb11 |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2122947Reactome: R-HSA-212436Reactome: R-HSA-2173796Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-381340Reactome: R-HSA-9833110 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclin-C antibodyAnti-Srb11 Homolog antibodyAnti-Hsrb11 antibodyAnti-CCNC antibody |
Information sourced from Uniprot.org
