Anti-CCNB1IP1 antibody (1-50) (STJ119107)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CCNB1IP1 (1-50) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CCNB1IP1 |
| Gene ID | 57820 |
| Uniprot ID | CIP1_HUMAN |
| Immunogen Region | 1-50 |
| Immunogen Sequence | MSLCEDMLLCNYRKCRIKLS GYAWVTACSHIFCDQHGSGE FSRSPAICPA |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-50 of human CCNB1IP1 (NP_878269.1). |
Additional Info
| Tissue Specificity | Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung. |
| Post Translational Modifications | Ubiquitinated.autoubiquitinated. Phosphorylated by CDK1 on serine or threonine residues (in vitro). |
| Function | Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ccnb1ip1Cyclin-B1-Interacting Protein 1Human Enhancer Of Invasion 10Ring-Type E3 Ubiquitin Transferase Ccnb1ip1 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeAssociates To The Synaptonemal Complex |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Ccnb1ip1 antibodyAnti-Cyclin-B1-Interacting Protein 1 antibodyAnti-Human Enhancer Of Invasion 10 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Ccnb1ip1 antibodyAnti-CCNB1IP1 antibodyAnti-C14orf18 antibodyAnti-HEI10 antibody |
Information sourced from Uniprot.org