Anti-CCNA1 antibody (350-450) (STJ116740)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CCNA1 (350-450) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CCNA1 |
| Gene ID | 8900 |
| Uniprot ID | CCNA1_HUMAN |
| Immunogen Region | 350-450 |
| Immunogen Sequence | YLRRQGVCVRTENLAKYVAE LSLLEADPFLKYLPSLIAAA AFCLANYTVNKHFWPETLAA FTGYSLSEIVPCLSELHKAY LDIPHRPQQAIREKYKASKY L |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human CCNA1 (NP_001104515.1). |
Additional Info
| Tissue Specificity | Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines. |
| Post Translational Modifications | Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. Ubiquitinated during the G1 phase by the SCF(FBXO31) complex, leading to its proteasomal degradation. |
| Function | May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. |
| Protein Name | Cyclin-A1 |
| Database Links | Reactome: R-HSA-1538133Reactome: R-HSA-170145Reactome: R-HSA-171319Reactome: R-HSA-174184Reactome: R-HSA-176408Reactome: R-HSA-187577Reactome: R-HSA-2559582Reactome: R-HSA-2559586Reactome: R-HSA-5689880Reactome: R-HSA-5693607Reactome: R-HSA-6804116Reactome: R-HSA-6804756Reactome: R-HSA-6804757Reactome: R-HSA-68911Reactome: R-HSA-68949Reactome: R-HSA-69017Reactome: R-HSA-69205Reactome: R-HSA-69273Reactome: R-HSA-69563Reactome: R-HSA-69656 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclin-A1 antibodyAnti-CCNA1 antibody |
Information sourced from Uniprot.org