Anti-CCM2 antibody (1-300) (STJ28627)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CCM2 (1-300) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CCM2 |
| Gene ID | 83605 |
| Uniprot ID | CCM2_HUMAN |
| Immunogen Region | 1-300 |
| Immunogen Sequence | MEEEGKKGKKPGIVSPFKRV FLKGEKSRDKKAHEKVTERR PLHTVVLSLPERVEPDRLLS DYIEKEVKYLGQLTSIPGYL NPSSRTEILHFIDNAKRAHQ LPGHLTQEHDAVLSLSAYNV KLAWRDGEDIILRVPIHDIA AVSYVRDDAAHLVVLKTAQD PGISPSQSLCAESSRGLSAG SLSESAVGPVEACCLVILAA ESKVAAEELCCLLGQVFQVV YTESTIDFLDRAIFDGAST |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CCM2 (NP_113631.1). |
Additional Info
| Function | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock. |
| Protein Name | Cerebral Cavernous Malformations 2 ProteinMalcavernin |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Cerebral Cavernous Malformations 2 Protein antibodyAnti-Malcavernin antibodyAnti-CCM2 antibodyAnti-C7orf22 antibodyAnti-PP10187 antibody |
Information sourced from Uniprot.org