| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-C-C motif chemokine 4 (41-90 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCL4 |
| Gene ID: | 388372/6351 |
| Uniprot ID: | CCL4_HUMAN |
| Immunogen Region: | 41-90 aa |
| Specificity: | MIP-1 Beta Polyclonal Antibody detects endogenous levels of MIP-1 Beta protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human CCL4 at the amino acid range 41-90 |
| Function | Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. |
| Protein Name | C-C Motif Chemokine 4 G-26 T-Lymphocyte-Secreted Protein Hc21 Lymphocyte Activation Gene 1 Protein Lag-1 Mip-1-Beta(1-69 Macrophage Inflammatory Protein 1-Beta Mip-1-Beta Pat 744 Protein H400 Sis-Gamma Small-Inducible Cytokine A4 T-Cell Activation Protein 2 Act-2 Cleaved Into - Mip-1-Beta(3-69 |
| Database Links | Reactome: R-HSA-380108 Reactome: R-HSA-418594 Reactome: R-HSA-6783783 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-C-C Motif Chemokine 4 antibody Anti-G-26 T-Lymphocyte-Secreted Protein antibody Anti-Hc21 antibody Anti-Lymphocyte Activation Gene 1 Protein antibody Anti-Lag-1 antibody Anti-Mip-1-Beta(1-69 antibody Anti-Macrophage Inflammatory Protein 1-Beta antibody Anti-Mip-1-Beta antibody Anti-Pat 744 antibody Anti-Protein H400 antibody Anti-Sis-Gamma antibody Anti-Small-Inducible Cytokine A4 antibody Anti-T-Cell Activation Protein 2 antibody Anti-Act-2 Cleaved Into - Mip-1-Beta(3-69 antibody Anti-CCL4 antibody Anti-LAG1 antibody Anti-MIP1B antibody Anti-SCYA4 antibody |
Information sourced from Uniprot.org