Anti-CCL22 antibody (31-80) (STJA0010152)

SKU:
STJA0010152

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-C-C motif chemokine 22 (31-80) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCL22
Gene ID: 6367
Uniprot ID: CCL22_HUMAN
Immunogen Region: 31-80
Specificity: This antibody detects endogenous levels of Human MDC
Immunogen: Synthesized peptide derived from human MDC AA range: 31-80
Tissue Specificity Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.
Post Translational Modifications The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.
Function May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.
Protein Name C-C Motif Chemokine 22
Cc Chemokine Stcp-1
Mdc(1-69
Macrophage-Derived Chemokine
Small-Inducible Cytokine A22
Stimulated T-Cell Chemotactic Protein 1 Cleaved Into - Mdc(3-69 - Mdc(5-69 - Mdc(7-69
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Cellular Localisation Secreted
Alternative Antibody Names Anti-C-C Motif Chemokine 22 antibody
Anti-Cc Chemokine Stcp-1 antibody
Anti-Mdc(1-69 antibody
Anti-Macrophage-Derived Chemokine antibody
Anti-Small-Inducible Cytokine A22 antibody
Anti-Stimulated T-Cell Chemotactic Protein 1 Cleaved Into - Mdc(3-69 - Mdc(5-69 - Mdc(7-69 antibody
Anti-CCL22 antibody
Anti-MDC antibody
Anti-SCYA22 antibody
Anti-A-152E5.1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance