| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CCL19 (22-95) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCL19 |
| Gene ID: |
6363 |
| Uniprot ID: |
CCL19_HUMAN |
| Immunogen Region: |
22-95 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 22-95 of human CCL19 (NP_006265.1). |
| Immunogen Sequence: |
GTNDAEDCCLSVTQKPIPGY IVRNFHYLLIKDGCRVPAVV FTTLRGRQLCAPPDQPWVER IIQRLQRTSAKMKR |
| Tissue Specificity | Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach. |
| Function | May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
| Protein Name | C-C Motif Chemokine 19Beta-Chemokine Exodus-3Ck Beta-11Epstein-Barr Virus-Induced Molecule 1 Ligand ChemokineEbi1 Ligand ChemokineElcMacrophage Inflammatory Protein 3 BetaMip-3-BetaSmall-Inducible Cytokine A19 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6783783 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-C-C Motif Chemokine 19 antibodyAnti-Beta-Chemokine Exodus-3 antibodyAnti-Ck Beta-11 antibodyAnti-Epstein-Barr Virus-Induced Molecule 1 Ligand Chemokine antibodyAnti-Ebi1 Ligand Chemokine antibodyAnti-Elc antibodyAnti-Macrophage Inflammatory Protein 3 Beta antibodyAnti-Mip-3-Beta antibodyAnti-Small-Inducible Cytokine A19 antibodyAnti-CCL19 antibodyAnti-ELC antibodyAnti-MIP3B antibodyAnti-SCYA19 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
