Anti-CCL19 antibody (22-95) (STJ119251)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CCL19 (22-95) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CCL19 |
| Gene ID | 6363 |
| Uniprot ID | CCL19_HUMAN |
| Immunogen Region | 22-95 |
| Immunogen Sequence | GTNDAEDCCLSVTQKPIPGY IVRNFHYLLIKDGCRVPAVV FTTLRGRQLCAPPDQPWVER IIQRLQRTSAKMKR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 22-95 of human CCL19 (NP_006265.1). |
Additional Info
| Tissue Specificity | Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach. |
| Function | May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
| Protein Name | C-C Motif Chemokine 19Beta-Chemokine Exodus-3Ck Beta-11Epstein-Barr Virus-Induced Molecule 1 Ligand ChemokineEbi1 Ligand ChemokineElcMacrophage Inflammatory Protein 3 BetaMip-3-BetaSmall-Inducible Cytokine A19 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6783783 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-C-C Motif Chemokine 19 antibodyAnti-Beta-Chemokine Exodus-3 antibodyAnti-Ck Beta-11 antibodyAnti-Epstein-Barr Virus-Induced Molecule 1 Ligand Chemokine antibodyAnti-Ebi1 Ligand Chemokine antibodyAnti-Elc antibodyAnti-Macrophage Inflammatory Protein 3 Beta antibodyAnti-Mip-3-Beta antibodyAnti-Small-Inducible Cytokine A19 antibodyAnti-CCL19 antibodyAnti-ELC antibodyAnti-MIP3B antibodyAnti-SCYA19 antibody |
Information sourced from Uniprot.org