Anti-CCL11/Eotaxin antibody (26-97 aa) [SRM5287] (STJ11107189)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal CCL11/Eotaxin (26-97 aa) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5287 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Ccl11 |
| Gene ID | 20292 |
| Uniprot ID | CCL11_MOUSE |
| Immunogen Region | 26-97 aa |
| Immunogen Sequence | GSIPTSCCFIMTSKKIPNTL LKSYKRITNNRCTLKAIVFK TRLGKEICADPKKKWVQDAT KHLDQKLQTPKP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 26-97 of mouse CCL11/Eotaxin (NP_035460.1). |
Additional Info
| Tissue Specificity | Expressed constitutively in the thymus. Expression inducible in the lung (type I alveolar epithelial cells), intestine, heart, spleen, kidney. |
| Function | In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils. Binds to CCR3. |
| Protein Name | EotaxinC-C Motif Chemokine 11Eosinophil Chemotactic ProteinSmall-Inducible Cytokine A11 |
| Database Links | Reactome: R-MMU-380108Reactome: -MMU-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Eotaxin antibodyAnti-C-C Motif Chemokine 11 antibodyAnti-Eosinophil Chemotactic Protein antibodyAnti-Small-Inducible Cytokine A11 antibodyAnti-Ccl11 antibodyAnti-Scya11 antibody |
Information sourced from Uniprot.org