Anti-CCKBR antibody (Internal) (STJ70710)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CCKBR (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 48-50kDa band observed in Mouse Pancreas lysates (calculated MW of 49.2kDa according to Mouse NP_031653.1) Recommended concentration: 0.3-1µg/ml. Primary incubation 1 hour at ro |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CCKBR |
| Gene ID | 887 |
| Uniprot ID | GASR_HUMAN |
| Accession Number | NP_795344.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | FDGDSDSDSQSRVRNQ |
Additional Info
| Function | Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism. |
| Protein Name | Gastrin/Cholecystokinin Type B ReceptorCck-B ReceptorCck-BrCholecystokinin-2 ReceptorCck2-R |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-881907 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Gastrin/Cholecystokinin Type B Receptor antibodyAnti-Cck-B Receptor antibodyAnti-Cck-Br antibodyAnti-Cholecystokinin-2 Receptor antibodyAnti-Cck2-R antibodyAnti-CCKBR antibodyAnti-CCKRB antibody |
Information sourced from Uniprot.org