Anti-CCDC98 antibody (350-400) {FITC} (STJ500026)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationFITC
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 350-400Β on ratΒ BRCA1-A complex subunit Abraxas protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-CCDC98 (350-400) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 0.52-0.63 Β΅g/Β΅l |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:50-1:150 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20Β°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ABRAXAS1 |
| Gene ID | 289468 |
| Uniprot ID | ABRX1_RAT |
| Immunogen | Synthetic peptide taken within amino acid region 350-400Β on ratΒ BRCA1-A complex subunit Abraxas protein. |
| Immunogen Region | 350-400 |
Additional Info
| Post Translational Modifications | Phosphorylation of Ser-402 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. |
| Function | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. |
| Protein Name | Brca1-A Complex Subunit Abraxas 1Coiled-Coil Domain-Containing Protein 98Protein Fam175a |
| Database Links | Reactome: R-RNO-5689901Reactome: -RNO-5693565Reactome: -RNO-5693571Reactome: -RNO-5693607Reactome: -RNO-69473 |
| Cellular Localisation | NucleusLocalizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs) |
| Alternative Antibody Names | Anti-Brca1-A Complex Subunit Abraxas 1 antibodyAnti-Coiled-Coil Domain-Containing Protein 98 antibodyAnti-Protein Fam175a antibodyAnti-ABRAXAS1 antibodyAnti-Abra1 antibodyAnti-Ccdc98 antibodyAnti-Fam175a antibody |
Information sourced from Uniprot.org