Anti-CCDC134 antibody (99-149 aa) (STJ195825)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CC134 at the amino acid range 99-149
General Information
| Short Description | Rabbit polyclonal anti-Coiled-coil domain-containing protein 134 (99-149 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CCDC134 |
| Gene ID | 79879 |
| Uniprot ID | CC134_HUMAN |
| Immunogen | Synthesized peptide derived from the human CC134 at the amino acid range 99-149 |
| Immunogen Region | 99-149 aa |
| Specificity | This antibody detects endogenous levels of CC134 at Human/Mouse/Rat |
Additional Info
| Post Translational Modifications | O-glycosylated, with additional sialic acid modifications. |
| Function | Molecular adapter required to prevent protein hyperglycosylation of HSP90B1: during translation, associates with nascent HSP90B1 and the STT3A catalytic component of the OST-A complex and tethers them to a specialized translocon that forms a microenvironment for HSP90B1 folding. In the CCDC134-containing translocon, STT3A associates with the SRT pseudosubstrate motif of HSP90B1, preventing access to facultative glycosylation sites until folding is completed, preventing hyperglycosylation and subsequent degradation of HSP90B1. In extracellular secreted form, promotes proliferation and activation of CD8(+) T-cells, suggesting a cytokine-like function. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling. May also localize in the nucleus: enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated histone acetyltransferase activity. Has a critical role in the regulation of osteogenesis and bone development. |
| Protein Name | Coiled-Coil Domain-Containing Protein 134 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum LumenSecretedCytoplasmNucleusMainly Localizes To The Endoplasmic ReticulumAccumulates In The Nucleus In Response To Uv Irradiation |
| Alternative Antibody Names | Anti-Coiled-Coil Domain-Containing Protein 134 antibodyAnti-CCDC134 antibody |
Information sourced from Uniprot.org