| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Coiled-coil domain-containing protein 134 (99-149 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCDC134 |
| Gene ID: | 79879 |
| Uniprot ID: | CC134_HUMAN |
| Immunogen Region: | 99-149 aa |
| Specificity: | This antibody detects endogenous levels of CC134 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human CC134 at the amino acid range 99-149 |
| Post Translational Modifications | O-glycosylated, with additional sialic acid modifications. |
| Function | In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling. Has a critical role in the regulation of osteogenesis and bone development. In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. |
| Protein Name | Coiled-Coil Domain-Containing Protein 134 |
| Cellular Localisation | Nucleus Cytoplasm Secreted Endoplasmic Reticulum Accumulates In The Nucleus In Response To Uv Irradiation |
| Alternative Antibody Names | Anti-Coiled-Coil Domain-Containing Protein 134 antibody Anti-CCDC134 antibody |
Information sourced from Uniprot.org