| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Coiled-coil domain-containing protein 115 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCDC115 |
| Gene ID: |
84317 |
| Uniprot ID: |
CC115_HUMAN |
| Specificity: |
This antibody detects endogenous levels of CCDC115 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human CCDC115 |
| Function | Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis. |
| Protein Name | Coiled-Coil Domain-Containing Protein 115 |
| Database Links | Reactome: R-HSA-8980692 |
| Cellular Localisation | EndosomeLysosomeEndoplasmic Reticulum-Golgi Intermediate CompartmentCytoplasmic VesicleCopi-Coated VesicleEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Coiled-Coil Domain-Containing Protein 115 antibodyAnti-CCDC115 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
