Anti-CCAR1 antibody (Internal) (STJ72101)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CCAR1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Rat/Dog/Cow/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 120kDa band observed in Mouse and Rat Skeletal Muscle lysates (calculated MW of 132kDa according to Mouse NP_080477.1 and Rat NP_001102005.1). Recommended concentration: 1-3µg/m |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CCAR1 |
| Gene ID | 55749 |
| Uniprot ID | CCAR1_HUMAN |
| Accession Number | NP_060707.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | RYCKERPSKDKE |
Additional Info
| Function | Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells. |
| Protein Name | Cell Division Cycle And Apoptosis Regulator Protein 1Cell Cycle And Apoptosis Regulatory Protein 1Carp-1Death Inducer With Sap Domain |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Cell Division Cycle And Apoptosis Regulator Protein 1 antibodyAnti-Cell Cycle And Apoptosis Regulatory Protein 1 antibodyAnti-Carp-1 antibodyAnti-Death Inducer With Sap Domain antibodyAnti-CCAR1 antibodyAnti-CARP1 antibodyAnti-DIS antibody |
Information sourced from Uniprot.org