| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CBX6 (200-250 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
CBX6 |
| Gene ID: |
23466 |
| Uniprot ID: |
CBX6_HUMAN |
| Immunogen Region: |
200-250 aa |
| Specificity: |
Specific for CBX6. |
| Immunogen: |
A synthetic peptide from aa region 200-250 of human CBX6 conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin. Recruitment to chromatin might occur in an H3K27me3-independent fashion. May have a PRC1-independent function in embryonic stem cells. |
| Protein Name | Chromobox Protein Homolog 6 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-8939243Reactome: R-HSA-8943724 |
| Cellular Localisation | NucleusChromosomeUniformely Distributed In The NucleoplasmLocalizes To The Inactivated X Chromosome In Females |
| Alternative Antibody Names | Anti-Chromobox Protein Homolog 6 antibodyAnti-CBX6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
