| Short Description : | Rabbit polyclonal anti-Chromobox protein homolog 6 (10-59 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CBX6 |
| Gene ID: | 23466 |
| Uniprot ID: | CBX6_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CBX6 at the amino acid range 10-59 |
| Immunogen Region: | 10-59 aa |
| Specificity: | CBX6 Polyclonal Antibody detects endogenous levels of CBX6 protein. |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin. Recruitment to chromatin might occur in an H3K27me3-independent fashion. May have a PRC1-independent function in embryonic stem cells. |
| Protein Name | Chromobox Protein Homolog 6 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-8939243Reactome: R-HSA-8943724 |
| Cellular Localisation | NucleusChromosomeUniformely Distributed In The NucleoplasmLocalizes To The Inactivated X Chromosome In Females |
| Alternative Antibody Names | Anti-Chromobox Protein Homolog 6 antibodyAnti-CBX6 antibody |
Information sourced from Uniprot.org
