| Function | Component of the heterotetramer complex KAR (3-ketoacyl-acyl carrier protein reductase or 3-ketoacyl-ACP reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-ACP to (3R)-hydroxyacyl-ACP in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). |
| Protein Name | 3-Oxoacyl-Acyl-Carrier-Protein Reductase3-Ketoacyl-Acyl-Carrier-Protein Reductase Beta SubunitKar Beta SubunitCarbonyl Reductase Family Member 4Cbr4Quinone Reductase Cbr4Short Chain Dehydrogenase/Reductase Family 45c Member 1 |
| Database Links | Reactome: R-HSA-75105 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-3-Oxoacyl-Acyl-Carrier-Protein Reductase antibodyAnti-3-Ketoacyl-Acyl-Carrier-Protein Reductase Beta Subunit antibodyAnti-Kar Beta Subunit antibodyAnti-Carbonyl Reductase Family Member 4 antibodyAnti-Cbr4 antibodyAnti-Quinone Reductase Cbr4 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 45c Member 1 antibodyAnti-CBR4 antibodyAnti-SDR45C1 antibody |
Information sourced from Uniprot.org
