Anti-CBLL1 antibody (STJA0007248)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human CBLL1
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase Hakai for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CBLL1 |
| Gene ID | 79872 |
| Uniprot ID | HAKAI_HUMAN |
| Immunogen | Synthesized peptide derived from human CBLL1 |
| Specificity | This antibody detects endogenous levels of CBLL1 at Human, Mouse |
Additional Info
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. |
| Protein Name | E3 Ubiquitin-Protein Ligase HakaiCasitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1C-Cbl-Like Protein 1Ring Finger Protein 188Ring-Type E3 Ubiquitin Transferase Hakai |
| Database Links | Reactome: R-HSA-8876493 |
| Cellular Localisation | Nucleus SpeckleNucleusNucleoplasmCytoplasmMainly Nuclear With Some Fraction Located In The CytoplasmZc3h13 Is Required To Anchor Component Of The Macom SubcomplexSuch As VirmaIn The Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hakai antibodyAnti-Casitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1 antibodyAnti-C-Cbl-Like Protein 1 antibodyAnti-Ring Finger Protein 188 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Hakai antibodyAnti-CBLL1 antibodyAnti-HAKAI antibodyAnti-RNF188 antibody |
Information sourced from Uniprot.org