Post Translational Modifications | Phosphorylated on tyrosine residues. |
Function | E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. |
Protein Name | E3 Ubiquitin-Protein Ligase HakaiCasitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1C-Cbl-Like Protein 1Ring Finger Protein 188Ring-Type E3 Ubiquitin Transferase Hakai |
Database Links | Reactome: R-HSA-8876493 |
Cellular Localisation | Nucleus SpeckleNucleusNucleoplasmCytoplasmMainly Nuclear With Some Fraction Located In The CytoplasmZc3h13 Is Required To Anchor Component Of The Macom SubcomplexSuch As VirmaIn The Nucleus |
Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hakai antibodyAnti-Casitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1 antibodyAnti-C-Cbl-Like Protein 1 antibodyAnti-Ring Finger Protein 188 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Hakai antibodyAnti-CBLL1 antibodyAnti-HAKAI antibodyAnti-RNF188 antibody |
Information sourced from Uniprot.org