| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CBLL1 (1-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CBLL1 |
| Gene ID: |
79872 |
| Uniprot ID: |
HAKAI_HUMAN |
| Immunogen Region: |
1-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human CBLL1 (NP_079090.2). |
| Immunogen Sequence: |
MDHTDNELQGTNSSGSLGGL DVRRRIPIKLISKQANKAKP APRTQRTINRMPAKAPPGDE EGFDYNEEERYDCKGGELFA NQRRFPGHLFWDFQINILGE KDDTPVHFCDKCGLPIKIYG RMIPCKHVFCYDCAILHEKK GDKMCPGCSDPVQRIEQCTR GSLFMCSIVQGCKRTYLSQR DLQAHINHRHMRAGKPVTRA SLENVHPPIAPPPTEIPERF IMPPDKHHMSHIPPKQHIM |
| Post Translational Modifications | Phosphorylated on tyrosine residues. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. |
| Protein Name | E3 Ubiquitin-Protein Ligase HakaiCasitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1C-Cbl-Like Protein 1Ring Finger Protein 188Ring-Type E3 Ubiquitin Transferase Hakai |
| Database Links | Reactome: R-HSA-8876493 |
| Cellular Localisation | Nucleus SpeckleNucleusNucleoplasmCytoplasmMainly Nuclear With Some Fraction Located In The CytoplasmZc3h13 Is Required To Anchor Component Of The Macom SubcomplexSuch As VirmaIn The Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hakai antibodyAnti-Casitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1 antibodyAnti-C-Cbl-Like Protein 1 antibodyAnti-Ring Finger Protein 188 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Hakai antibodyAnti-CBLL1 antibodyAnti-HAKAI antibodyAnti-RNF188 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
