| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CBLC (245-474) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CBLC |
| Gene ID: |
23624 |
| Uniprot ID: |
CBLC_HUMAN |
| Immunogen Region: |
245-474 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 245-474 of human CBLC (NP_036248.3). |
| Immunogen Sequence: |
DEVQERLQACRDKPGSYIFR PSCTRLGQWAIGYVSSDGSI LQTIPANKPLSQVLLEGQKD GFYLYPDGKTHNPDLTELGQ AEPQQRIHVSEEQLQLYWAM DSTFELCKICAESNKDVKIE PCGHLLCSCCLAAWQHSDSQ TCPFCRCEIKGWEAVSIYQF HGQATAEDSGNSSDQEGREL ELGQVPLSAPPLPPRPDLPP RKPRNAQPKVRLLKGNSPPA ALGPQDPAPA |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated on multiple tyrosine residues by SRC. Isoform 1, but not isoform 2, is phosphorylated on tyrosines by EGFR. Autoubiquitinated when phosphorylated at Tyr-341, enhanced by SRC.suggesting proteasomal degradation. |
| Function | Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction.upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation.CD2AP converts it from an inhibitor to a promoter of RET degradation.the function limits the potency of GDNF on neuronal survival. |
| Protein Name | E3 Ubiquitin-Protein Ligase Cbl-CRing Finger Protein 57Ring-Type E3 Ubiquitin Transferase Cbl-CSh3-Binding Protein Cbl-3Sh3-Binding Protein Cbl-CSignal Transduction Protein Cbl-C |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Cbl-C antibodyAnti-Ring Finger Protein 57 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Cbl-C antibodyAnti-Sh3-Binding Protein Cbl-3 antibodyAnti-Sh3-Binding Protein Cbl-C antibodyAnti-Signal Transduction Protein Cbl-C antibodyAnti-CBLC antibodyAnti-CBL3 antibodyAnti-RNF57 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
