Anti-CAV3 antibody (STJA0008134)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Caveolin-3
General Information
| Short Description | Rabbit polyclonal anti-Caveolin-3 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CAV3 |
| Gene ID | 859 |
| Uniprot ID | CAV3_HUMAN |
| Immunogen | Synthesized peptide derived from human Caveolin-3 |
| Specificity | This antibody detects endogenous levels of Caveolin-3 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2. |
| Function | May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. |
| Protein Name | Caveolin-3M-Caveolin |
| Database Links | Reactome: R-HSA-445355 |
| Cellular Localisation | Golgi Apparatus MembranePeripheral Membrane ProteinCell MembraneMembraneCaveolaSarcolemmaPotential Hairpin-Like Structure In The MembraneMembrane Protein Of Caveolae |
| Alternative Antibody Names | Anti-Caveolin-3 antibodyAnti-M-Caveolin antibodyAnti-CAV3 antibody |
Information sourced from Uniprot.org