| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow/Pig |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-CAV3 (N-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-Recommended concentration, 3-5µg/mlELISA-antibody detection limit dilution 1:4000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
CAV3 |
| Gene ID: |
859 |
| Uniprot ID: |
CAV3_HUMAN |
| Immunogen Region: |
N-Term |
| Accession Number: |
NP_203123.1 |
| Specificity: |
Reported variants represent identical protein (NP_001225.1; NP_203123.1). |
| Immunogen Sequence: |
EHTDLEAQIVKDIH |
| Post Translational Modifications | Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2. |
| Function | May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. |
| Protein Name | Caveolin-3M-Caveolin |
| Database Links | Reactome: R-HSA-445355 |
| Cellular Localisation | Golgi Apparatus MembranePeripheral Membrane ProteinCell MembraneMembraneCaveolaSarcolemmaPotential Hairpin-Like Structure In The MembraneMembrane Protein Of Caveolae |
| Alternative Antibody Names | Anti-Caveolin-3 antibodyAnti-M-Caveolin antibodyAnti-CAV3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
