Anti-CASTOR2 antibody (79-129 aa) (STJ195572)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human GATL2 at the amino acid range 79-129
General Information
| Short Description | Rabbit polyclonal anti-Cytosolic arginine sensor for mTORC1 subunit 2 (79-129 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CASTOR2 |
| Gene ID | 729438 |
| Uniprot ID | CAST2_HUMAN |
| Immunogen | Synthesized peptide derived from the human GATL2 at the amino acid range 79-129 |
| Immunogen Region | 79-129 aa |
| Specificity | This antibody detects endogenous levels of GATL2 at Human/Mouse |
Additional Info
| Function | Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. |
| Protein Name | Cytosolic Arginine Sensor For Mtorc1 Subunit 2Cellular Arginine Sensor For Mtorc1 Protein 2Gats-Like Protein 2 |
| Database Links | Reactome: R-HSA-9639288 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Cytosolic Arginine Sensor For Mtorc1 Subunit 2 antibodyAnti-Cellular Arginine Sensor For Mtorc1 Protein 2 antibodyAnti-Gats-Like Protein 2 antibodyAnti-CASTOR2 antibodyAnti-GATSL1 antibodyAnti-GATSL2 antibody |
Information sourced from Uniprot.org