Anti-Caspase 10 antibody [R03-2J3] (STJA0034108)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human Caspase-10
General Information
| Short Description | Rabbit monoclonal anti-Caspase 10 for use in WB, IHC-P and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-2J3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CASP10 |
| Gene ID | 843 |
| Uniprot ID | CASPA_HUMAN |
| Immunogen | Recombinant protein of human Caspase-10 |
Additional Info
| Tissue Specificity | Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon. |
| Post Translational Modifications | Cleavage by granzyme B and autocatalytic activity generate the two active subunits. |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive. |
| Protein Name | Caspase-10Casp-10Apoptotic Protease Mch-4Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2Flice2Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 |
| Database Links | Reactome: R-HSA-6803207Reactome: R-HSA-75157Reactome: R-HSA-75158Reactome: R-HSA-933543 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Caspase-10 antibodyAnti-Casp-10 antibodyAnti-Apoptotic Protease Mch-4 antibodyAnti-Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2 antibodyAnti-Flice2 antibodyAnti-Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 antibodyAnti-CASP10 antibodyAnti-MCH4 antibody |
Information sourced from Uniprot.org