Anti-CASP8AP2 antibody (1733-1982) (STJ118215)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CASP8AP2 (1733-1982) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CASP8AP2 |
| Gene ID | 9994 |
| Uniprot ID | C8AP2_HUMAN |
| Immunogen Region | 1733-1982 |
| Immunogen Sequence | TVGAFIDLTQDASSEAKSEG NHPALAVEDLGCGVIQVDED NCKEEKAQVANRPLKCIVEE TYIDLTTESPSSCEVKKDEL KSEPGSNCDNSELPGTLHNS HKKRRNISDLNHPHKKQRKE TDLTNKEKTKKPTQDSCENT EAHQKKASKKKAPPVTKDPS SLKATPGIKDSSAALATSTS LSAKNVIKKKGEIIILWTRN DDREILLECQKRGPSFKTFA YLAAKLDKNPNQVSERFQQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1733-1982 of human CASP8AP2 (NP_036247.1). |
Additional Info
| Function | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. |
| Protein Name | Casp8-Associated Protein 2Flice-Associated Huge Protein |
| Database Links | Reactome: R-HSA-3899300 |
| Cellular Localisation | CytoplasmNucleusPml BodyMitochondrionExported From The Nucleus To The Mitochondria Upon Fas Activation |
| Alternative Antibody Names | Anti-Casp8-Associated Protein 2 antibodyAnti-Flice-Associated Huge Protein antibodyAnti-CASP8AP2 antibodyAnti-FLASH antibodyAnti-KIAA1315 antibodyAnti-RIP25 antibody |
Information sourced from Uniprot.org