• Western blot analysis of various lysates using CASP8AP2 Rabbit polyclonal antibody (STJ118215) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-CASP8AP2 antibody (1733-1982) (STJ118215)

SKU:
STJ118215

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CASP8AP2 (1733-1982) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CASP8AP2
Gene ID: 9994
Uniprot ID: C8AP2_HUMAN
Immunogen Region: 1733-1982
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1733-1982 of human CASP8AP2 (NP_036247.1).
Immunogen Sequence: TVGAFIDLTQDASSEAKSEG NHPALAVEDLGCGVIQVDED NCKEEKAQVANRPLKCIVEE TYIDLTTESPSSCEVKKDEL KSEPGSNCDNSELPGTLHNS HKKRRNISDLNHPHKKQRKE TDLTNKEKTKKPTQDSCENT EAHQKKASKKKAPPVTKDPS SLKATPGIKDSSAALATSTS LSAKNVIKKKGEIIILWTRN DDREILLECQKRGPSFKTFA YLAAKLDKNPNQVSERFQQ
Function Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
Protein Name Casp8-Associated Protein 2
Flice-Associated Huge Protein
Database Links Reactome: R-HSA-3899300
Cellular Localisation Cytoplasm
Nucleus
Pml Body
Mitochondrion
Exported From The Nucleus To The Mitochondria Upon Fas Activation
Alternative Antibody Names Anti-Casp8-Associated Protein 2 antibody
Anti-Flice-Associated Huge Protein antibody
Anti-CASP8AP2 antibody
Anti-FLASH antibody
Anti-KIAA1315 antibody
Anti-RIP25 antibody

Information sourced from Uniprot.org

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