Anti-CASP2 antibody (334-452) [S1MR] (STJ11102181)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Caspase-2 (334-452) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S1MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CASP2 |
| Gene ID | 835 |
| Uniprot ID | CASP2_HUMAN |
| Immunogen Region | 334-452 |
| Immunogen Sequence | GKNHTQSPGCEESDAGKEEL MKMRLPTRSDMICGYACLKG NAAMRNTKRGSWYIEALTQV FSERACDMHVADMLVKVNAL IKEREGYAPGTEFHRCKEMS EYCSTLCQQLYLFPGYPPT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 334-452 of human Caspase-2 (P29594). |
Additional Info
| Tissue Specificity | Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle. |
| Post Translational Modifications | The mature protease can process its own propeptide, but not that of other caspases. |
| Function | Is a regulator of the cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress. Isoform 1: Acts as a positive regulator of apoptosis. Isoform 2: Acts as a negative regulator of apoptosis. Isoform 3: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. |
| Protein Name | Caspase-2Casp-2Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2Nedd-2Protease Ich-1 Cleaved Into - Caspase-2 Subunit P18 - Caspase-2 Subunit P13 - Caspase-2 Subunit P12 |
| Database Links | Reactome: R-HSA-168638Reactome: R-HSA-205025Reactome: R-HSA-6803207 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Caspase-2 antibodyAnti-Casp-2 antibodyAnti-Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2 antibodyAnti-Nedd-2 antibodyAnti-Protease Ich-1 Cleaved Into - Caspase-2 Subunit P18 - Caspase-2 Subunit P13 - Caspase-2 Subunit P12 antibodyAnti-CASP2 antibodyAnti-ICH1 antibodyAnti-NEDD2 antibody |
Information sourced from Uniprot.org