| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Caspase-10 (220-521) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CASP10 |
| Gene ID: |
843 |
| Uniprot ID: |
CASPA_HUMAN |
| Immunogen Region: |
220-521 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 220-521 of human Caspase-10 (NP_116759.2). |
| Immunogen Sequence: |
VKTFLEALPQESWQNKHAGS NGNRATNGAPSLVSRGMQGA SANTLNSETSTKRAAVYRMN RNHRGLCVIVNNHSFTSLKD RQGTHKDAEILSHVFQWLGF TVHIHNNVTKVEMEMVLQKQ KCNPAHADGDCFVFCILTHG RFGAVYSSDEALIPIREIMS HFTALQCPRLAEKPKLFFIQ ACQGEEIQPSVSIEADALNP EQAPTSLQDSIPAEADFLLG LATVPGYVSFRHVEEGSWY |
| Tissue Specificity | Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon. |
| Post Translational Modifications | Cleavage by granzyme B and autocatalytic activity generate the two active subunits. |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive. |
| Protein Name | Caspase-10Casp-10Apoptotic Protease Mch-4Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2Flice2Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 |
| Database Links | Reactome: R-HSA-6803207Reactome: R-HSA-75157Reactome: R-HSA-75158Reactome: R-HSA-933543 |
| Alternative Antibody Names | Anti-Caspase-10 antibodyAnti-Casp-10 antibodyAnti-Apoptotic Protease Mch-4 antibodyAnti-Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2 antibodyAnti-Flice2 antibodyAnti-Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 antibodyAnti-CASP10 antibodyAnti-MCH4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
