Anti-Casein kinase I isoform alpha antibody (Full-Length) (STJA0040646)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenShortest isoform of recombinant full length CK1a.
General Information
| Short Description | Chicken polyclonal anti-Casein kinase I isoform alpha (Full-Length) for use in ICC, IHC-F and WB in Bovine, Chicken, Horse, Human, Mouse, Pig and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ICC/IHC-F/WB |
| Host | Chicken |
| Reactivity | Bovine/Chicken/Horse/Human/Mouse/Pig/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Purification | IgY preparation |
| Dilution Range | WB 1:5000-1:10000ICC 1:500-1:1000 |
| Formulation | Lyophilized IgY preparation, with sodium azide. |
| Storage Instruction | Spin vial briefly before opening. Reconstitute with 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution of lyophilized antibody, aliquot and store at-20°C for a higher stability. Avoid freeze-th |
Target Information
| Gene Symbol | CSNK1A1 |
| Gene ID | 1452 |
| Uniprot ID | KC1A_HUMAN |
| Immunogen | Shortest isoform of recombinant full length CK1a. |
| Immunogen Region | Full-Length |
| Immunogen Sequence | Human |
| Specificity | Antibody recognizes CK1 by Western blot and immunohistochemistry. Cross reactivity. |
Additional Info
| Post Translational Modifications | Phosphorylated by MTOR in response to mitogenic stimulation, leading to its activation. |
| Function | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor. Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3. |
| Protein Name | Casein Kinase I Isoform AlphaCki-AlphaCk1 |
| Database Links | Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-5610783Reactome: R-HSA-5610785Reactome: R-HSA-5635838Reactome: R-HSA-9694631 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeChromosomeCentromereKinetochoreNucleus SpeckleCilium Basal BodySpindleLocalizes To The Centrosome In Interphase CellsAnd To Kinetochore Fibers During MitosisAlso Recruited To The Keratin Cytoskeleton |
| Alternative Antibody Names | Anti-Casein Kinase I Isoform Alpha antibodyAnti-Cki-Alpha antibodyAnti-Ck1 antibodyAnti-CSNK1A1 antibody |
Information sourced from Uniprot.org