Anti-Casein kinase 1 alpha/CSNK1A1 antibody (1-337aa) [AT2E2] (STJA0041922)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenRecombinant human Casein Kinase 1 alpha (1-337aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-Casein kinase 1 alpha/CSNK1A1 (1-337aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT2E2 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-G affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CSNK1A1 |
| Gene ID | 1452 |
| Uniprot ID | KC1A_HUMAN |
| Accession Number | NP_001883 |
| Immunogen | Recombinant human Casein Kinase 1 alpha (1-337aa) purified from E. coli |
| Immunogen Region | 1-337aa |
Additional Info
| Post Translational Modifications | Phosphorylated by MTOR in response to mitogenic stimulation, leading to its activation. |
| Function | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor. Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3. |
| Protein Name | Casein Kinase I Isoform AlphaCki-AlphaCk1 |
| Database Links | Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-5610783Reactome: R-HSA-5610785Reactome: R-HSA-5635838Reactome: R-HSA-9694631 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeChromosomeCentromereKinetochoreNucleus SpeckleCilium Basal BodySpindleLocalizes To The Centrosome In Interphase CellsAnd To Kinetochore Fibers During MitosisAlso Recruited To The Keratin Cytoskeleton |
| Alternative Antibody Names | Anti-Casein Kinase I Isoform Alpha antibodyAnti-Cki-Alpha antibodyAnti-Ck1 antibodyAnti-CSNK1A1 antibody |
Information sourced from Uniprot.org