Anti-Carcinoembryonic Antigen antibody [PARLAM4] (STJ16100878)

SKU:
STJ16100878-1

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Host: Mouse
Applications: IHC-F/IHC-P/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Carcinoembryonic antigen is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality: Monoclonal
Clone ID: PARLAM4
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Contains 0.09% sodium azide
Dilution Range: IHC-F
IHC-P 1:5-1:10
WB
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: CEACAM5
Gene ID: 1048
Uniprot ID: CEAM5_HUMAN
Immunogen: Isolated from human colon carcinoma cells
Tissue Specificity Expressed in columnar epithelial and goblet cells of the colon (at protein level). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Post Translational Modifications Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
Function Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression.induces resistance to anoikis of colorectal carcinoma cells. (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
Protein Name Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5
Carcinoembryonic Antigen
Cea
Meconium Antigen 100
Cd Antigen Cd66e
Database Links Reactome: R-HSA-163125
Reactome: R-HSA-202733
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Apical Cell Membrane
Cell Surface
Localized To The Apical Glycocalyx Surface
Alternative Antibody Names Anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 antibody
Anti-Carcinoembryonic Antigen antibody
Anti-Cea antibody
Anti-Meconium Antigen 100 antibody
Anti-Cd Antigen Cd66e antibody
Anti-CEACAM5 antibody
Anti-CEA antibody

Information sourced from Uniprot.org

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