• Anti-Carbonic Anhydrase antibody [TH22] (STJ16101687)

Anti-Carbonic Anhydrase antibody [TH22] (STJ16101687)

SKU:
STJ16101687-1

£629.50
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Carbonic Anhydrase is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: TH22
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: Tissue culture supernatant with 15mM sodium azide
Concentration: >=21 mg/L
Dilution Range: IHC-P 1:100
Storage Instruction: Store at 2-8°C upon receipt.
Immunogen: Prokaryotic recombinant protein corresponding to 118 amino acids of the human Carbonic Anhydrase IX molecule.
Background Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. Originally named MN/G250, carbonic anhydrase IX (CAIX) is a cell surface transmembrane protein, which is predominantly found in the gastrointestinal tract and gallbladder. The glandular regions of normal colon are reported to be negative, but in the case of adenocarcinoma, the glands are positive. CAIX is also reported to be expressed in common epithelial tumors such as carcinomas of the esophagus, lung, colon, kidney, cervix and non-small cell lung carcinoma.In breast carcinomas, CAIX expression has been reported to be associated with malignant tissue. Expression of CAIX is reported to be absent in normal kidney, chromophobe carcinomas or oncocytomas; however, it is specifically expressed in clear cell renal carcinomas.

Information sourced from Uniprot.org

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