Anti-CAPRIN1 antibody (STJA0006747)

SKU:
STJA0006747

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Caprin-1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CAPRIN1
Gene ID: 4076
Uniprot ID: CAPR1_HUMAN
Specificity: This antibody detects endogenous levels of CAPRIN1 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human CAPRIN1
Post Translational Modifications Tyrosine phosphorylation by EPHA4 promotes interaction with FMR1 and liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. O-glycosylation by OGT inhibit ability to undergo liquid-liquid phase separation (LLPS).
Function mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs. In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation. Binds directly and selectively to MYC and CCND2 mRNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.
Protein Name Caprin-1
Cell Cycle-Associated Protein 1
Cytoplasmic Activation- And Proliferation-Associated Protein 1
Gpi-Anchored Membrane Protein 1
Gpi-Anchored Protein P137
Gpi-P137
P137gpi
Membrane Component Chromosome 11 Surface Marker 1
Rna Granule Protein 105
Cellular Localisation Cytoplasm
Cytoplasmic Ribonucleoprotein Granule
Cytosol
Cell Projection
Dendrite
Lamellipodium
Mediates Formation And Localizes To Cytoplasmic Ribonucleoprotein Membraneless Compartments
Associated With Rna Granules
At The Leading Edge Of Migrating Fibroblasts
Colocalizes With Ddx3x
Alternative Antibody Names Anti-Caprin-1 antibody
Anti-Cell Cycle-Associated Protein 1 antibody
Anti-Cytoplasmic Activation- And Proliferation-Associated Protein 1 antibody
Anti-Gpi-Anchored Membrane Protein 1 antibody
Anti-Gpi-Anchored Protein P137 antibody
Anti-Gpi-P137 antibody
Anti-P137gpi antibody
Anti-Membrane Component Chromosome 11 Surface Marker 1 antibody
Anti-Rna Granule Protein 105 antibody
Anti-CAPRIN1 antibody
Anti-GPIAP1 antibody
Anti-GPIP137 antibody
Anti-M11S1 antibody
Anti-RNG105 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance