Anti-CAPON/NOS1AP antibody (N-Term) (STJ70232)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CAPON/NOS1AP (N-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:1000.IHC: In paraffin embedded Human Brain shows localized cytoplasm staining in the neuronal cells. Recommended concentration, 4-6µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | NOS1AP |
| Gene ID | 9722 |
| Uniprot ID | CAPON_HUMAN |
| Accession Number | NP_055512.1; NP_001158229.1 |
| Immunogen Region | N-Term |
| Immunogen Sequence | PSKTKYNLVDDGH |
| Specificity | This antibody is expected to recognise both reported isoforms. |
Additional Info
| Function | Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation. |
| Protein Name | Carboxyl-Terminal Pdz Ligand Of Neuronal Nitric Oxide Synthase ProteinC-Terminal Pdz Ligand Of Neuronal Nitric Oxide Synthase ProteinNitric Oxide Synthase 1 Adaptor Protein |
| Cellular Localisation | Cell ProjectionFilopodiumPodosome |
| Alternative Antibody Names | Anti-Carboxyl-Terminal Pdz Ligand Of Neuronal Nitric Oxide Synthase Protein antibodyAnti-C-Terminal Pdz Ligand Of Neuronal Nitric Oxide Synthase Protein antibodyAnti-Nitric Oxide Synthase 1 Adaptor Protein antibodyAnti-NOS1AP antibodyAnti-CAPON antibodyAnti-KIAA0464 antibody |
Information sourced from Uniprot.org