Anti-CAPN1 antibody (STJ192952)

SKU:
STJ192952

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Calpain-1 catalytic subunit is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CAPN1
Gene ID: 823
Uniprot ID: CAN1_HUMAN
Specificity: CAN1 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms.
Function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409'. Cleaves and activates caspase-7 (CASP7).
Protein Name Calpain-1 Catalytic Subunit
Calcium-Activated Neutral Proteinase 1
Canp 1
Calpain Mu-Type
Calpain-1 Large Subunit
Cell Proliferation-Inducing Gene 30 Protein
Micromolar-Calpain
Mucanp
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-6798695
Reactome: R-HSA-6809371
Reactome: R-HSA-8862803
Cellular Localisation Cytoplasm
Cell Membrane
Translocates To The Plasma Membrane Upon Ca(2+) Binding
In Granular Keratinocytes And In Lower Corneocytes
Colocalizes With Flg And Flg2
Alternative Antibody Names Anti-Calpain-1 Catalytic Subunit antibody
Anti-Calcium-Activated Neutral Proteinase 1 antibody
Anti-Canp 1 antibody
Anti-Calpain Mu-Type antibody
Anti-Calpain-1 Large Subunit antibody
Anti-Cell Proliferation-Inducing Gene 30 Protein antibody
Anti-Micromolar-Calpain antibody
Anti-Mucanp antibody
Anti-CAPN1 antibody
Anti-CANPL1 antibody
Anti-PIG30 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance